CEREBROPROTECTIVE ACTIVITY OF OUINAZOLINE-4(3H)-ONE DERIVATIVES WITH A GUANIDINE SUBSTITUENT IN RATS WITH BILATERAL COMMON CAROTID ARTERY OCCLUSION
| Autor: | A. V Borisov, E. V Volotova, A. A Ozerov, D. V Kurkin, D. A Bakulin, E. E Abrosimova, L. E Borodkina, J. A Smolnyakova |
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| Rok vydání: | 2021 |
| Zdroj: | Journal of Volgograd State Medical University. 18:97-102 |
| ISSN: | 1994-9499 1994-9480 |
| Popis: | From derivatives of quinazolin-4 (3H) -one, 2 substances were isolated: VMA-13-15 (N-[2-[4-oxo-3(4H)-quinazolinyl] propionyl]guanidine) and VMA-13-17 (N-[2-[6-bromo-4-oxo-3(4H)-quinazolinyl]acetyl]guanidine). With the therapeutic administration of the compounds, the survival rate and neurological condition of animals with bilateral occlusion of the common carotid arteries were better than in the control group. Also 72 hours after surgery and treatment, the level of cerebral blood flow and the severity of the reactions of cerebral vessels to the introduction of a stimulant and a blocker of nitric oxide synthesis were higher. Compounds VMA-13-15 and VMA-13-17 are promising for further study of their therapeutic potential in cerebrovascular accidents. |
| Databáze: | OpenAIRE |
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