The effect of specific modifications of the amine ligands on the solubility, stability, CO release to myoglobin and whole blood, cell toxicity and haemolytic index of [Mo(CO)4(NR3)2] complexes
| Autor: | Lukas Adrian Kromer, Ana Rita Marques, Isabel Bento, Carlos Jose Romao, Ana C. Coelho |
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| Rok vydání: | 2014 |
| Předmět: |
Denticity
Aqueous solution medicine.diagnostic_test Tertiary amine Ligand Organic Chemistry Inorganic chemistry Biochemistry Medicinal chemistry 3. Good health Inorganic Chemistry chemistry.chemical_compound Myoglobin chemistry Spectrophotometry Materials Chemistry medicine Amine gas treating Physical and Theoretical Chemistry Solubility |
| Zdroj: | Journal of Organometallic Chemistry. 760:89-100 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2013.12.009 |
| Popis: | A series of cis-[Mo(CO)4(amine)2] complexes (NR3 = morpholine 1; 4-Me–piperazine, 2; H2NCH2CH2NH2, 3; H2NCH2CH2–morpholine (4) R2NCH2CH2–piperazine–4-Me (R = H, 5); R = Me, 6); Me2NCH2CH2NMe2, 7) was prepared in good yields, in a one-step microwave-assisted synthesis. The X-ray diffraction structures of the complexes 4, 5 and 6 are reported. The stability of the complexes 1–7 in aqueous, aerobic media was studied by UV–Vis spectrophotometry, RP-HPLC and gas chromatography at several pH values. Stability beyond 1 h requires bidentate ligands with at least one tertiary amine ligand and increases in the order 4 2 > 3 > 4 > 5 > 6 >> 7, but it is much faster to whole blood. The haemolytic index of some compounds increases in a similar order: 1 |
| Databáze: | OpenAIRE |
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