A 1-year study of two doses of steroid in combination with methotrexate and chloroquine in the treatment of patients with mild and moderate systemic lupus erythematosus

Autor:	Li Li, Shun-Le Chen, Daniel E. Furst, Ting Li, Sheng Chen, Chun-De Bao
Rok vydání:	2006
Předmět:	medicine.medical_specialty business.industry Retrospective cohort study Pharmacology medicine.disease Group A Gastroenterology Group B Cushing syndrome Rheumatology Prednisone Chloroquine Internal medicine medicine Methotrexate business Adverse effect medicine.drug
Zdroj:	APLAR Journal of Rheumatology. 9:392-396
ISSN:	1479-8077 0219-0494
DOI:	10.1111/j.1479-8077.2006.00243.x
Popis:	Aim: This is a retrospective study on the efficacy and adverse effects of treating mild or moderate systemic lupus erythematosus without major organ involvement using small dosage prednisone combined with MTX and chloroquine (PMC). Methods: As a retrospective 1-year follow-up study, clinic outpatients (Rheumatology Department, Renji Hospital, Shanghai, China) were divided by predinisone dose (Group A, prednisone ≤ 0.2 mg/kg/d; Group B prednisone 0.5–0.6 mg/kg/d). All patients (N = 30 per group) were also administered methotrexate (7.5–10 mg/week) and chloroquine (250 mg/d). Efficacy and adverse effects of the two protocol drug regimens were compared. Results: The OUT Score of Group A was reduced from 2.10 ± 1.45 to 0.94 ± 0.73, and Group B from 2.93 ± 2.26 to 1.3 ± 1.29. The treatment was successful and there was no significant difference of efficacy between these two groups. However, the infection rate was much higher in Group B than in Group A (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d7f6e212a12236726165154637f74ff https://doi.org/10.1111/j.1479-8077.2006.00243.x Zobrazit plný text záznamu Plný text ve formátu PDF