IgG4-related disease manifesting the gastric wall thickening
| Autor: | Hideharu Hironaka, Michitaka Kawano, Tokuhiro Kimura, Shoko Matsui, Michiya Yamaguchi, Kenji Notohara, Tsuyoshi Takahashi, Hiroo Kawano, Makoto Kubo, Aya Ishii, Eiji Ikeda, Keiji Oishi |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty integumentary system medicine.diagnostic_test business.industry fungi General Medicine medicine.disease Malignancy Pathology and Forensic Medicine Pathogenesis 03 medical and health sciences Pneumonia 0302 clinical medicine medicine.anatomical_structure Fibrosis 030220 oncology & carcinogenesis Submucosa parasitic diseases medicine Blood test 030211 gastroenterology & hepatology IgG4-related disease Differential diagnosis business |
| Zdroj: | Pathology International. 66:23-28 |
| ISSN: | 1320-5463 |
| DOI: | 10.1111/pin.12364 |
| Popis: | IgG4-related disease (IgG4-RD) is a recently designated disease entity and its full picture has not yet been elucidated. Here, we report an unusual case of a patient with gastric wall thickening secondary to IgG4-RD. A 68-year-old male visited our hospital with itchy skin lesions and an episode of organizing pneumonia. On the suspicion of malignancy-associated skin lesions, computed tomography (CT) was performed. The CT revealed prominent thickening of the gastric wall. Due to the possibility of malignancy, the patient underwent distal gastrectomy. Histopathological examination showed fibrosis of the submucosa and prominent thickening of the muscularis propria. Most of infiltrating cells were IgG4-positive plasma cells. Post-operative blood test revealed significantly high serum levels of total IgG and IgG4. Based on these histological features, the patient was given a definitive diagnosis of IgG4-RD. Further accumulation of cases like the present case that develop IgG4-RD with rare manifestations would lead to the elucidation of pathogenesis. |
| Databáze: | OpenAIRE |
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