Bargellini condensation of coumarins. Expeditious route to o-carboxyvinylphenoxyisobutyric acids and application to the synthesis of sesquiterpenes helianane, heliannuol A and heliannuol C

Autor:	Ramanathapuram V. Venkateswaran, Bidyut Biswas, Prabir K. Sen
Rok vydání:	2007
Předmět:	chemistry.chemical_compound Ring-closing metathesis Chloroform chemistry Aqueous sodium hydroxide Organic Chemistry Drug Discovery Condensation Acetone Organic chemistry Biochemistry
Zdroj:	Tetrahedron. 63:12026-12036
ISSN:	0040-4020
DOI:	10.1016/j.tet.2007.09.006
Popis:	The direct Bargellini condensation of coumarins involving reaction with chloroform and acetone in the presence of aqueous sodium hydroxide furnished o -carboxyvinylphenoxyisobutyric acids in good yields. The utility of this new useful protocol was demonstrated by the transformation of the three diesters 9b , 9f and 9g to the sesquiterpenes helianane 4 , heliannuol A 2 and heliannuol C 3 , respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d6ba86d24c6882139c9f1c30a0f748d https://doi.org/10.1016/j.tet.2007.09.006 Zobrazit plný text záznamu Full Text from ScienceDirect