In vivoEffects of Black Cohosh and Genistein on Estrogenic Activity and Lipid Peroxidation in Japanese Medaka (Oryzias latipes)

Autor:	Luling Zhang, Kristine L. Willett, Ikhlas A. Khan, Christy M. Foran
Rok vydání:	2003
Předmět:	Pharmacology medicine.medical_specialty biology medicine.drug_class Chemistry Oryzias Black cohosh Genistein Japanese Medaka biology.organism_classification Biochemistry Lipid peroxidation chemistry.chemical_compound Endocrinology In vivo Estrogen Internal medicine medicine Testosterone
Zdroj:	Journal of Herbal Pharmacotherapy. 3:33-50
ISSN:	1522-9106 1522-8940
DOI:	10.1080/j157v03n03_04
Popis:	This study was designed to assay the estrogenic activities and the antioxidant potential of ethanol extracts from the herbal dietary supplement black cohosh (Cimicifuga racemosa) relative to the natural phytoestrogen genistein. The in vivo mechanisms of action of these two natural products have not been completely elucidated, and Japanese medaka (Oryzias latipes) provides a useful organism for initial in vivo screening of natural products. While both genistein and estradiol altered ovarian and testicular steroid release and decreased circulating testosterone levels in males, neither black cohosh total extract (75–30,000 ng/fish), cimiracemoside A, 25-O-methyl-cimigenoside, actein, nor 26-deoxy-actein caused any differences in estrogenic activity compared to control fish. To assess antioxidant potential, animals were treated with natural products then challenged with 2-acetylaminofluorene (2-AAF) to induce lipid peroxidation (LPO) in the liver. Neither the total ethanol extracts from black cohosh nor its i...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d691816c0df4739c74d4b969bb1582d https://doi.org/10.1080/j157v03n03_04 Zobrazit plný text záznamu