Design and operation of a filter reactor for continuous production of a selected pharmaceutical intermediate
| Autor: | Thomas Lønberg Holm, Michael Jønch Pedersen, Søren Kiil, Kim Dam-Johansen, Kim Müller Christensen, Tommy Skovby |
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| Rok vydání: | 2012 |
| Předmět: |
Chemistry
business.industry Applied Mathematics General Chemical Engineering Side reaction Continuous stirred-tank reactor General Chemistry Chemical reactor Industrial and Manufacturing Engineering Continuous production Solvent Filter (video) Slurry Plug flow reactor model Process engineering business |
| Zdroj: | Chemical Engineering Science. 71:111-117 |
| ISSN: | 0009-2509 |
| DOI: | 10.1016/j.ces.2011.12.002 |
| Popis: | A novel filter reactor system for continuous production of selected pharmaceutical intermediates is presented and experimentally verified. The filter reactor system consists of a mixed flow reactor equipped with a bottom filter, to retain solid reactant particles, followed by a conventional plug flow reactor, where residual reactant is converted by titration. A chemical case study, production of the pharmaceutical intermediate allylcarbinol by a reaction between allylmagnesium chloride and 2-chloro-thioxanthone, in the presence of a side reaction is considered. The synthesis is conducted in tetrahydrofuran solvent. The use of the filter reactor design was explored by examining the transferability of a synthesis step in a present full-scale semi-batch pharmaceutical production into continuous processing. The main advantages of the new continuous minireactor system, compared to the conventional semi-batch operation, are reduced impurity formation and the use of much lower reactor volumes (factor of 1000 based on the laboratory reactor) and less solvent consumption (from 5.8 to 2.3 L/kg reactant). Added challenges include handling of continuous solid powder feeding, stable pumping of reactive slurries, and a possibility of continuous control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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