Efficient catalytic enantioselective mannich-type reactions using a zirconium-bis(binaphthol)methane complex

Autor:	Takayuki Kitazawa, Haruro Ishitani, Shu Kobayashi
Rok vydání:	1999
Předmět:	chemistry.chemical_classification Aldimine Zirconium Silylation Organic Chemistry Enantioselective synthesis chemistry.chemical_element Biochemistry Methane Adduct Catalysis chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Enantiomer
Zdroj:	Tetrahedron Letters. 40:2161-2164
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)00138-0
Popis:	In the presence of a catalytic amount of a zirconium-bis(binaphthol)methane complex (5), Mannich-type reactions of aldimines with silyl enolates proceeded smoothly to afford the corresponding adducts in high yields with high enantiomeric excesses. (R)-(R)-Bis(3-BINOL)methane 6, that was prepared by linking two binaphthols, was shown to be very effective in these reactions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d62044bda24234849251bb1776b6aaa https://doi.org/10.1016/s0040-4039(99)00138-0 Zobrazit plný text záznamu Full Text from ScienceDirect