Autor:	Joseph G. Ibrahim, Marian Ewell
Rok vydání:	1997
Předmět:	Log-rank test Distribution (number theory) Sample size determination Applied Mathematics Statistics Econometrics General Medicine Conditional probability distribution Statistic Mathematics Large sample
Zdroj:	Lifetime Data Analysis. 3:5-12
ISSN:	1380-7870
DOI:	10.1023/a:1009690200504
Popis:	We derive the large sample distribution of the weighted log rank statistic under a general class of local alternatives in which both the cure rates and the conditional distribution of time to failure among those who fail are assumed to vary in the two treatment arms. The analytic result presented here is important to data analysts who are designing clinical trials for diseases such as non-Hodgkins lymphoma, leukemia and melanoma, where a significant proportion of patients are cured. We present a numerical illustration comparing powers obtained from the analytic result to those obtained from simulations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d50f79118136e7edeffe669046b2b27 https://doi.org/10.1023/a:1009690200504 Zobrazit plný text záznamu Full text from SpringerLink