| Popis: |
We are in the midst of a therapeutic revolution for patients with melanoma. This chapter reviews several topics on melanoma from epidemiologic trends, to the evolution of the surgical approach, to adjuvant treatment of melanoma, and also reviews various systemic therapies for metastatic melanoma. Each component of this chapter describes advances from a historical perspective, beginning with the first descriptions of melanoma in the literature, to the discovery of activating B-raf mutations in melanoma, and concluding with the current immune and targeted based therapies for advanced melanoma. It serves as a segue to the more detailed therapies and advances in the ensuing chapters. |
