| Popis: |
Background Adenocarcinoma of the lung is the most common pathological subtype. This paper is to investigate the relationship between endoplasmic reticulum-related LncRNA and prognosis of patients with lung adenocarcinomaMethod A total 295 ER stress-related genes are downloaded from the GSEA website and the TCGA website was obtained for TCGA-LUAD patient profiles and mutation data. Co-expression analysis, the univariate cox regression and Least Absolute Shrinkage and Selection Operator Cox regression was performed on significantly expressed LncRNAs. Next, a risk model was developed using multifactorial analysis to classify patients into different risk groups. Survival analysis and nomogram were also constructed and evaluated for patients in different groups. Finally, the tumor microenvironment and immune landscape were explored.Result 14 genes found to be strongly associated with patient prognosis. Risk score models were created and patients were grouped using risk score. Clinical variables and signature were also used to build the nomogram with perfect prediction function. The AUC value for 1,3,5 are respectively 0.739,0.734,0.753. The human immune response and Neutrophil extracellular trap formation are related to signature. Immune responses, immune cells, and immunological checkpoints were found to be considerably different. Last, We screened for sensitive drugs.Conclusion Collectively, we found that 14 ERS-related Lncrna signature was meaningful in predicting patient response to immunotherapy. |
