166 DO TROPHOBLASTIC RECEPTORS FOR INSULIN, IGF-I, AND IGF-II PLAY A ROLE IN FETAL OVERGROWTH IN DIABETIC PREGNANCY?

Autor:	Rulynn Fuong, Regina A Jansons, H David Mosier, Floyd L. Culler
Rok vydání:	1994
Předmět:	Fetus medicine.medical_specialty Cord business.industry Insulin medicine.medical_treatment medicine.disease medicine.anatomical_structure Endocrinology Cell surface receptor Internal medicine Placenta Pediatrics Perinatology and Child Health medicine Mass index business Receptor Hyperinsulinism
Zdroj:	Pediatric Research. 36:30A-30A
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199407000-00166
Popis:	Fetal overgrowth in diabetic pregnancy (DP) is popularly attributed to hyperinsulinism. However, the roles of other growth-promoting peptides in the mother and the fetus and of their receptors in the placenta remain unclear. We measured at term, concentration and affinity of placental trophoblastic membrane receptors (TR) for insulin (I), IGF-I and IGF-II in 8 DP's (White Class B, 1-dependent) and 8 non-DP's and correlated these with maternal and cord serum IGF-I and IGF-II levels, infant and placenta weights, and maternal body mass index (BMI). DP and non-DP differed significantly in infant weight (g), 4248±114 (M±SEM) vs 3555±119 (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d298a2c437a8e5049386ce4cdce3603 https://doi.org/10.1203/00006450-199407000-00166 Zobrazit plný text záznamu