Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment

Autor: Monika Kostoska, Lea Taneska, Elena Markova, Maja Simonoska Crcarevska, Ivana Dimitrovska, Vasil Makrievski, Tanja Olumceva, Jovica Todorov, Dushko Shalabalija, Marija Glavas Dodov, Marija Petrushevska, Riste Popeski Dimovski, Ljubica Mihailova
Rok vydání: 2020
Předmět:
Zdroj: Cellulose. 27:7109-7126
ISSN: 1572-882X
0969-0239
DOI: 10.1007/s10570-020-03283-7
Popis: This study describes development of a dosage form for acne treatment. A topical semi-solid dosage form—gel with clindamycin-hydrochloride (CM-HCl) loaded ethyl cellulose based microsponges (MSP). Central composite experimental design was used for optimization of the formulation in means of particle size and drug loading. CM-HCl MSP optimal formulation was prepared and characterized in aspect of: particle size (D50-14.9 μm) and particle size distribution (Span-1.979); shape (spherical) and morphology (porous); FTIR spectra; drug content (CM-HCl/polymer (mg/mg)-1.2544) and drug release with mean dissolution time (MDT) of 4.51 h. Chitosan (2%) was used as a gelling agent for the optimal sample formulation. The gel showed pseudoplastic behavior and high value of spreading capacity (263.64% spreading after 5 min). It was translucent without presence of foreign particles and had typical light-yellow colour, pH value of 5.36 ± 0.15 and MDT of 7.17 h. Stability studies performed at 25° ± 2 °C/60% ± 5% RH and 40° ± 2 °C/75% ± 5% RH for a period of 6 months were in favor of the stability of the designed topical semi-solid dosage form.
Databáze: OpenAIRE
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