Novel amphiphilic compounds for the design of stimulus-sensitive liposomal containers

Autor:	D. A. Davydov, Vladimir A. Palyulin, V. L. Lapteva, Alexander A. Yaroslavov, Nikolay S. Zefirov, Polina N. Veremeeva
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Liposome Enzyme Aqueous solution Chemistry Bilayer Amphiphile Biophysics Organic chemistry Biological activity General Chemistry Lipid bilayer
Zdroj:	Doklady Chemistry. 447:275-277
ISSN:	1608-3113 0012-5008
Popis:	The development of methods for the directed transport of biologically active compounds (BACs) to target cells and organs is a crucial task of pharmacol� ogy [1]. Liposomes, hollow particles whose aqueous interior is separated from an external aqueous solution by a bilayer lipid membrane, are often used as contain� ers for BAC immobilization [2]. To increase the thera� peutic effect of encapsulated BAC, the liposome sur� face is modified in such a manner that the release of BAC occurs in the region of its delivery target. The release of BAC from liposomes is initiated by different methods, for example, by changing the temperature and pH of a medium, complexation, and enzymatic cleavage of labile chemical bonds [3–5].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d1a03435bfa062ed7e0aba4dcde7ed3 https://doi.org/10.1134/s0012500812120051 Zobrazit plný text záznamu Plný text ve formátu PDF