A Prospective, Longitudinal Magnetic Resonance Imaging Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis

Autor: Niral J Patel, Larry T Davis, Meher R. Juttukonda, Chelsea A Lee, Sarah K Lants, Lori C. Jordan, Manus J. Donahue, Spencer L. Waddle
Rok vydání: 2021
Předmět:
Zdroj: Journal of Magnetic Resonance Imaging. 54:912-922
ISSN: 1522-2586
1053-1807
Popis: BACKGROUND Patients with symptomatic atherosclerotic and non-atherosclerotic (i.e., moyamoya) intracranial steno-occlusive disease experience high 2-year infarct rates. PURPOSE To investigate whether cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) measures may provide biomarkers of 1-to-2-year infarct risk. STUDY TYPE Prospective, longitudinal study. SUBJECTS Adult participants (age = 18-85 years) with symptomatic intracranial atherosclerotic disease (N = 26) or non-atherosclerotic (i.e., moyamoya; N = 43) and stenosis ≥50% of a major intracranial artery were initially scanned within 45 days of stroke. Follow-up imaging (target = 1.5 years) was acquired for new infarct assessment. FIELD STRENGTH/SEQUENCE 3.0 Tesla with normocapnic arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) imaging acquired during an interleaved hypercapnic (3 minutes) and normocapnic (3 minutes) respiratory stimulus. ASSESSMENT CBF, maximum CVR, and time-to-maximum CVR (i.e., CVRDELAY ) were calculated. Laterality indices (difference between infarcted and contralesional hemispheres divided by sum of absolute values) of metrics at enrollment were contrasted between participants with vs. without new infarcts on follow-up. STATISTICAL TESTS Laterality indices were compared using non-parametric Wilcoxon tests (significance: two-sided P
Databáze: OpenAIRE
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