A Prospective, Longitudinal Magnetic Resonance Imaging Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis
Autor: | Niral J Patel, Larry T Davis, Meher R. Juttukonda, Chelsea A Lee, Sarah K Lants, Lori C. Jordan, Manus J. Donahue, Spencer L. Waddle |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Longitudinal study medicine.diagnostic_test business.industry Intracranial Artery Magnetic resonance imaging medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences Stenosis 0302 clinical medicine Cerebral blood flow Internal medicine Laterality medicine Cardiology Radiology Nuclear Medicine and imaging Stage (cooking) business Stroke |
Zdroj: | Journal of Magnetic Resonance Imaging. 54:912-922 |
ISSN: | 1522-2586 1053-1807 |
Popis: | BACKGROUND Patients with symptomatic atherosclerotic and non-atherosclerotic (i.e., moyamoya) intracranial steno-occlusive disease experience high 2-year infarct rates. PURPOSE To investigate whether cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) measures may provide biomarkers of 1-to-2-year infarct risk. STUDY TYPE Prospective, longitudinal study. SUBJECTS Adult participants (age = 18-85 years) with symptomatic intracranial atherosclerotic disease (N = 26) or non-atherosclerotic (i.e., moyamoya; N = 43) and stenosis ≥50% of a major intracranial artery were initially scanned within 45 days of stroke. Follow-up imaging (target = 1.5 years) was acquired for new infarct assessment. FIELD STRENGTH/SEQUENCE 3.0 Tesla with normocapnic arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) imaging acquired during an interleaved hypercapnic (3 minutes) and normocapnic (3 minutes) respiratory stimulus. ASSESSMENT CBF, maximum CVR, and time-to-maximum CVR (i.e., CVRDELAY ) were calculated. Laterality indices (difference between infarcted and contralesional hemispheres divided by sum of absolute values) of metrics at enrollment were contrasted between participants with vs. without new infarcts on follow-up. STATISTICAL TESTS Laterality indices were compared using non-parametric Wilcoxon tests (significance: two-sided P |
Databáze: | OpenAIRE |
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