Pseudomonas aeruginosa vaccine and pseudomonas antiserum in the treatment and prevention of infections in burned patients
| Autor: | Meitert E, Savulian Cornelia, Agr. Ionescu, Milicescu S, T. Meitert, Stela Vasiliu, F. Sima |
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| Rok vydání: | 1980 |
| Předmět: |
Serotype
medicine.medical_specialty biology business.industry Pseudomonas aeruginosa Incidence (epidemiology) medicine.medical_treatment Pseudomonas General Medicine Immunotherapy Critical Care and Intensive Care Medicine biology.organism_classification medicine.disease_cause medicine.disease Gastroenterology Immunity Pseudomonas infection Internal medicine Immunology Emergency Medicine biology.protein Medicine Surgery Antibody business |
| Zdroj: | Burns. 7:1-9 |
| ISSN: | 0305-4179 |
| DOI: | 10.1016/0305-4179(80)90002-9 |
| Popis: | Two hundred and ten patients with various severe burns were followed up clinically, bacteriologically and immunologically; 162 patients received a polyvalent pseudomonas vaccine (23 for treatment, 139 preventively), 5 patients received combined immunotherapy (polyvalent pseudomonas vaccine and serum) and 43 patients were not vaccinated (control group). Of the 23 patients treated immediately after the onset of pseudomonas infection, 18 recovered clinically and bacteriologically, the other 5 patients died after 39–137 days from Pseudomonas aeruginosa septicaemia (1 case) or other causes (4 cases). In the control group (25 non-vaccinated patients) 5 patients died from P. aeruginosa infections. The combined immunotherapy applied in 5 patients with severe burns predominantly infected with P. aeruginosa led to conspicuous improvement of their general condition and progress towards clinical and bacteriological recovery. Polyvalent pseudomonas vaccine applied preventively 2 years consecutively (1977, 1978) in the same hospital lowered the incidence of P. aeruginosa both in the vaccinated and non-vaccinated patients (from 47.6 per cent in 1977 to 7.2 per cent in 1978 in the vaccinated patients, and from 76 per cent in 1977 to 33.3 per cent in 1978 in the non-vaccinated patients). Active anti-pseudomonas immunity induced by the polyvalent pseudomonas vaccine (prepared from 11 different P. aeruginosa serotypes) in burned patients, systematically followed up in 167 cases, was confirmed by the steadily rising curve of serum immunoglobulin values (IgG, IgA, IgM) and seroprotection titres. |
| Databáze: | OpenAIRE |
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