ChemInform Abstract: Catalytic Asymmetric Formal Insertion of Aryldiazoalkanes into the C-H Bond of Aldehydes: Synthesis of Enantioenriched Acyclic α-Tertiary Aryl Ketones

Autor:	Byung Chul Kang, Do Hyun Ryu, Geum-Sook Hwang, Dong Guk Nam
Rok vydání:	2016
Předmět:	chemistry.chemical_compound C h bond chemistry Aryl Enantioselective synthesis chemistry.chemical_element General Medicine Lewis acids and bases Boron Medicinal chemistry Catalysis
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201608025
Popis:	A novel, catalytic enantioselective route to synthesize a variety of α-tertiary aryl ketones via a boron Lewis acid promoted formal insertion of aryldiazoalkane into the C–H bond of both aromatic and aliphatic aldehydes is described. In the presence of chiral (S)-oxazaborolidinium ion catalyst 1, the reaction proceeded in good yields (up to 94%) with excellent enantioselectivities (up to 99% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2d088a4f3165ba7814caab21e95c8e83 https://doi.org/10.1002/chin.201608025 Zobrazit plný text záznamu Plný text