Regulatory systems that mediate the effects of temperature on the lifespan ofCaenorhabditis elegans
| Autor: | Young-Hun Kim, Jongsun Lee, Seung-Jae Lee, Byounghun Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
biology Nematode caenorhabditis elegans ved/biology Autophagy ved/biology.organism_classification_rank.species Lipid signaling biology.organism_classification Cell biology 03 medical and health sciences Cellular and Molecular Neuroscience 030104 developmental biology 0302 clinical medicine Proteostasis Genetics TRPA Model organism 030217 neurology & neurosurgery Organism Caenorhabditis elegans |
| Zdroj: | Journal of Neurogenetics. 34:518-526 |
| ISSN: | 1563-5260 0167-7063 |
| Popis: | Temperature affects animal physiology, including aging and lifespan. How temperature and biological systems interact to influence aging and lifespan has been investigated using model organisms, including the nematode Caenorhabditis elegans. In this review, we discuss mechanisms by which diverse cellular factors modulate the effects of ambient temperatures on aging and lifespan in C. elegans. C. elegans thermosensory neurons alleviate lifespan-shortening effects of high temperatures via sterol endocrine signaling and probably through systemic regulation of cytosolic proteostasis. At low temperatures, C. elegans displays a long lifespan by upregulating the cold-sensing TRPA channel, lipid homeostasis, germline-mediated prostaglandin signaling, and autophagy. In addition, co-chaperone p23 amplifies lifespan changes affected by high and low temperatures. Our review summarizes how external temperatures modulate C. elegans lifespan and provides information regarding responses of biological processes to temperature changes, which may affect health and aging at an organism level. |
| Databáze: | OpenAIRE |
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