Synthesis of [c]-Fused Bicyclic Proline Analogues

Autor:	Francisco J. Sayago, M. Isabel Calaza, Pedro Laborda, Carlos Cativiela
Rok vydání:	2015
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Enantiopure drug chemistry Bicyclic molecule Stereochemistry Organic Chemistry Moiety Proline Physical and Theoretical Chemistry Ring (chemistry) Pyrrolidine Amino acid
Zdroj:	European Journal of Organic Chemistry. 2015:1633-1658
ISSN:	1434-193X
DOI:	10.1002/ejoc.201403121
Popis:	An overview of synthetic methods developed to build [c]-fused bicyclic proline analogues is presented. The focus is on the preparation of azabicycles that bear a carbocyclic ring fused to the [c] face of the pyrrolidine unit. Attention is paid both to procedures that afford the desired compounds in racemic form and to asymmetric strategies. Procedures are organized according to the size of the carbocycle that is fused to the pyrrolidine moiety. Strategies able to provide multigram quantities of enantiopure compounds that have application in the synthesis of marketed drugs are highlighted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cff07cdf55cbdfe8fadd148e513e3a5 https://doi.org/10.1002/ejoc.201403121 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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