The Role of Biomarkers in Drug Discovery and Development: Enabling PK/PD

Autor:	Erick Kindt, Gabriella Szekely‐Klepser
Rok vydání:	2012
Předmět:	Pharmaceutical drug Drug Drug discovery business.industry medicine.medical_treatment media_common.quotation_subject Translational research Bioinformatics Pharmacokinetics Pharmacodynamics medicine Biomarker (medicine) business PK/PD models media_common
Zdroj:	Encyclopedia of Drug Metabolism and Interactions
DOI:	10.1002/9780470921920.edm111
Popis:	The goal of drug discovery and development is to find the right drug and to administer it at the right dose with the right frequency to the right patient. Biomarkers can be an invaluable tool to enable meeting this goal by confirming the efficacy and safety of drug candidates, providing an understanding of their mechanism of action, and determining the efficacious dose and dosing regimen by establishing the correlation between the pharmacokinetics (PK) and pharmacodynamics (PD) of the drugs. This chapter provides a definition of biomarkers and illustrates their roles and applications in pharmaceutical drug development. Keywords: biomarker; PK/PD modeling; drug discovery and development; translational research; fit-for-purpose assay validation
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cfb619d2d81d1b7fe89452c7cbf26fb https://doi.org/10.1002/9780470921920.edm111 Zobrazit plný text záznamu