Reactivation of Epstein-Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites on the Viral Genome
| Autor: | Laura E. M. Dunn, Fang Lu, Chenhe Su, Paul M. Lieberman, Joel D. Baines |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Virology. 97 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.01894-22 |
| Popis: | The ability of EBV to switch between latent and lytic infection is key to its long-term persistence in memory B cells, and its ability to persist in proliferating cells is strongly linked to oncogenesis. During latency, most viral genes are epigenetically silenced, and the virus must overcome this repression to reactivate lytic replication. |
| Databáze: | OpenAIRE |
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