α-Glucosidase Inhibitory Isomeric Corniculatolides from the Stems of the Indian Mangrove Plant, Xylocarpus granatum
| Autor: | Bolatito Eunice Olanipekun, Karimulla Shaik, Vamsi Krishna Kommalapati, Jagadeesh B. Nanubolu, Mangala Gowri Ponnapalli, Anjana Devi Tangutur |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Chloroform biology 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Saccharomyces cerevisiae Pharmaceutical Science Crystallographic data biology.organism_classification 01 natural sciences 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine DU145 Xylocarpus granatum Drug Discovery Molecular Medicine Mangrove α glucosidase inhibitory IC50 |
| Zdroj: | Journal of Natural Products. 83:20-25 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00414 |
| Popis: | Three new isomeric corniculatolides (1, 2, and 3) with an unusual caffrane and isocorniculane framework, and five known metabolites were isolated from the chloroform extract of the stems of Xylocarpus granatum. The structures of the new metabolites were deduced as corniculatolide B (1), isocorniculatolide B (2), and corniculatolide C (3) by spectroscopic data analysis and a combination of chemical transformations and supported by single-crystal X-ray crystallographic data of 1 and 3. The isolated compounds were evaluated for their in vitro cytotoxicity and α-glucosidase (Saccharomyces cerevisiae) inhibitory potential. Compound 3 possessed α-glucosidase inhibitory activity with an IC50 value of 24.8 μM, whereas these rare macrolides showed no effect on the mammalian cancer cell lines MIAPaCa-2, DU145, MCF-7, and HTC-116. |
| Databáze: | OpenAIRE |
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