Dichlorphenamide, a potent carbonic anhydrase inhibitor
| Autor: | Theodore Rodman, Ronald Dorris, Joseph V. Olivia |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Chronic respiratory acidosis
medicine.medical_specialty biology business.industry medicine.drug_class Metabolic acidosis General Medicine Pharmacology medicine.disease Pulmonary function testing Surgery Respiratory acidosis Carbonic anhydrase medicine biology.protein Arterial blood Carbonic anhydrase inhibitor medicine.symptom business Acidosis |
| Zdroj: | The American Journal of Medicine. 36:79-86 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(64)90150-0 |
| Popis: | Detailed studies of pulmonary function were made in patients with chronic respiratory acidosis before and during the administration of a new carbonic anhydrase inhibitor, dichlorphenamide. No basic alteration in pulmonary function was observed, but there was an impressive fall in arterial plasma carbon dioxide content related to the metabolic acidosis induced by the inhibition of renal tubular carbonic anhydrase. The ventilatory compensation for this metabolic acidosis was imperfect, particularly in the patients with the most advanced lung disease. The effect of erythrocyte carbonic anhydrase inhibition is discussed. It is pointed out that the presence of this enzyme in the red blood cell is essential for normal carbon dioxide pick up and transport from the tissues to the alveoli and that inhibition of the enzyme is followed by accumulation of carbon dioxide in the tissues and production of a carbon dioxide gradient between the tissues and the venous blood and between the pulmonary arterial blood and alveolar air. It is concluded that there is little or no place for the use of carbonic anhydrase inhibitors in the treatment of respiratory acidosis. |
| Databáze: | OpenAIRE |
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