Electromyographic Manifestations of Hereditary Signs of Extrapyramidal Insufficiency

Autor: N. M. Berezetskaya, M. A.Chivliklii, I. N. Karaban, E. P. Lukhanina, N. A. Pil’kevich
Rok vydání: 2010
Předmět:
Zdroj: Neurophysiology. 42:39-49
ISSN: 1573-9007
0090-2977
DOI: 10.1007/s11062-010-9129-5
Popis: In clinically healthy kinsmen of patients suffering from Parkinson’s disease, we studied the amplitude/frequency characteristics of EMG activity recorded from flexors and extensors of the elbow joint in order to reveal symptoms of extrapyramidal insufficiency (EPI) in these persons and to propose necessary recommendations to such a risk group. We examined four groups of persons: group 1 consisting of 37 healthy kinsmen of patients with clinical diagnosis of Parkinson’s disease; control group 2 consisting of 20 tested persons whose age was analogous to that of persons of group 1; group 3 including 33 Parkinsonian patients; and group 4 of 24 virtually healthy persons of elderly age, i.e., the group considered to be the control one with respect to group 3. In Parkinsonian patients, the main EPI correlates were the following: (i) significantly increased amplitude of EMG recorded from the arm muscles in the resting state, (ii) bursting discharges in such EMGs generated with a 4-9 sec–1 frequency (type III of EMG), and (iii) abnormally increased coefficients of reflex involvement (CRI) for the muscles of the opposite arm at retention of a load by one arm. One symptom of EPI or another were found in 20 (54.1%) kinsmen of the Parkinsonian patients; in this case, increased EMG amplitudes were observed in 13 persons (35.1%). We also observed significant correlation of the level of rise in the amplitude of the resting EMG with the age of the tested persons. In 29.7% kinsmen of the Parkinsonian patients, burst discharges with a 5-10 sec–1 frequency were present in their EMGs, while in 16.2% of these persons we observed increased CRIs at retention of a load. For comparison, in the corresponding control group, increased amplitudes of the resting EMG, generation of burst EMG dischargers, and increased CRIs were observed in 15, 5, and 10% of the tested persons, respectively. Therefore, in kinsmen of the Parkinsonian patients, some EMG EPI manifestations were observed 2.3 to 5.9 times more frequently that those in the corresponding control group. For the members of the risk group, recommendations concerning the daily routine (mode of life) and the dietary intake, as well as a list of drugs to be avoided for long-term administration, were proposed.
Databáze: OpenAIRE
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