ChemInform Abstract: Efficient and Convenient Pyridine Ring-E Formation of the Cytotoxic Marine Alkaloid Ascididemin and Related Analogues

Autor:	Allison Pearce, Brent S. Lindsay, Brent R. Copp
Rok vydání:	2010
Předmět:	Acetic acid chemistry.chemical_compound chemistry Stereochemistry Alkaloid Yield (chemistry) Pyridine Ammonium chloride General Medicine Ring (chemistry) Paraformaldehyde Quinone
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199742264
Popis:	Conversion of tetracyclic quinone 1 to the cytotoxic pentacyclic alkaloid ascididemin (2) in 80% yield is achieved by reaction with paraformaldehyde and ammonium chloride in refluxing acetic acid. High yielding annelations are aiso observed for the related analogues N-8 deaza ascididemin (3) and kuanoniamine A (4).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cdb180a3d4496426408393ecee18540 https://doi.org/10.1002/chin.199742264 Zobrazit plný text záznamu Plný text