Antimicrobial resistance and risk factors for mortality of pneumonia caused by Klebsiella pneumoniae among diabetics: a retrospective study conducted in Shanghai, China
| Autor: | Yi Guo, Jie Fang, Huahua Yi, Bing Liu, Lizhong Han, Min Zhou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Klebsiella pneumoniae Cefotetan 030106 microbiology Meropenem law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine Pharmacology (medical) 030212 general & internal medicine Risk factor Pharmacology biology business.industry Retrospective cohort study biology.organism_classification medicine.disease Intensive care unit Pneumonia Infectious Diseases Amikacin business medicine.drug |
| Zdroj: | Infection and Drug Resistance. 12:1089-1098 |
| ISSN: | 1178-6973 |
| Popis: | Purpose: To investigate antimicrobial resistance and risk factors for mortality of Klebsiella pneumoniae (KP) pneumonia in diabetics and nondiabetics. Patients and methods: A retrospective study was conducted among inpatients of KP pneumonia via electronic medical records in a territory hospital between January 2016 and June 2018. Antimicrobial resistance in KP pneumonia was compared between diabetics and nondiabetics. Independent risk factors for mortality in KP pneumonia were identified by univariate and multivariate logistic regression among diabetics and nondiabetics separately. Results: In this study, 456 patients with KP pneumonia were included. There were 156 cases with diabetes and 300 without diabetes. KP showed a lower antimicrobial resistance to a multitude of antimicrobials in pneumonia among diabetics than nondiabetics, namely aztreonam, cefotetan, sulperazone, meropenem, amikacin, tobramycin, sulfamethoxazole, and fosfomycin. In addition, carbapenem-resistant Klebsiella pneumoniae (CRKP) was more prevalent among nondiabetics than diabetics who were admitted to intensive care unit (ICU) (63.0% vs 45.1%, P = 0.038). Multivariable analysis showed that independent risk factors for in-hospital mortality (IHM) in KP pneumonia among diabetics differed from that among nondiabetics as well. Independent predictors for IHM of KP pneumonia among diabetics were male (OR: 5.89, 95% CI: 1.34-25.93, P = 0.019), albumin (ALB) < 35 g/L (OR: 7.00, 95% CI: 2.02-24.28, P = 0.002), bloodstream infection (BSI) (OR: 21.14, 95% CI: 3.18-140.72, P = 0.002), and invasive ventilation during hospitalization (OR: 8.00, 95% CI: 2.99-21.42, P < 0.001). In nondiabetics, independent predictors were higher CURB-65 score (OR: 1.92, 95% CI: 1.29-2.86, P = 0.001), CRKP (OR: 2.72, 95% CI: 1.07-6.90, P = 0.035), BSI (OR: 4.98, 95% CI: 1.34-18.50, P = 0.017), and ICU admission (OR: 4.06, 95% CI: 1.57-10.47, P = 0.004). Conclusion: In KP pneumonia, diabetics showed lower antimicrobial resistance and different independent risk factors for mortality compared with nondiabetics, in line with previous studies. Importantly, further attention should be paid on rational and effective antibiotic and supportive treatments in order to reduce mortality without aggravating antimicrobial resistance and metabolic damage among diabetics. |
| Databáze: | OpenAIRE |
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