Scaled-Up Transition-Metal-Catalyzed Cross-Coupling Reactions of Thioether-Substituted N-Heterocycles with Organozinc Reagents

Autor:	Paul Knochel, Albrecht Metzger, Laurin Melzig
Rok vydání:	2010
Předmět:	inorganic chemicals Organic Chemistry chemistry.chemical_element Copper Catalysis Coupling reaction chemistry.chemical_compound Nickel Thioether chemistry Transition metal Reagent Polymer chemistry Organic chemistry Palladium
Zdroj:	Synthesis. 2010:2853-2858
ISSN:	1437-210X 0039-7881
DOI:	10.1055/s-0030-1258145
Popis:	A variety of functionalized methylthio-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, quinazolines, benzothiazoles) undergo smooth palladium- or nickel-catalyzed cross-couplings with highly functionalized organozinc reagents at ambient temperature. No expensive copper(I) salts are required and the coupling reactions proceed readily in the range of up to 20 mmol scale.
Databáze:	OpenAIRE
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