LaF3:Tb3+ − Bengal Rose nanocomplexes for X-ray activated ROS generation
| Autor: | Alexander V. Sorokin, Pavel Maksimchuk, I. A. Borovoy, S. L. Yefimova, I.I. Bespalova, K.O. Hubenko |
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| Rok vydání: | 2021 |
| Předmět: |
Chemistry
Singlet oxygen medicine.medical_treatment Radical chemistry.chemical_element Photodynamic therapy Condensed Matter Physics Photochemistry Oxygen Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials chemistry.chemical_compound Materials Chemistry medicine Rose bengal Molecule Photosensitizer Irradiation Physical and Theoretical Chemistry Spectroscopy |
| Zdroj: | Journal of Molecular Liquids. 330:115653 |
| ISSN: | 0167-7322 |
| Popis: | Herein we report the creation of nanocomplexes on the base of scintillation nanoparticles (SNPs) LaF3:Tb3+ and organic photosensitizer Rose Bengal (RB) with an efficient electronic excitation energy transfer upon both UV-light and X-ray irradiation. In such LaF3:Tb3+ − RB complexes, SNPs act as an energy transducer absorbing high-energy photons and transferring them to the organic RB photosensitizer with subsequent singlet oxygen 1O2 generation for X-ray activated photodynamic therapy (PDT). For the first time, it has been shown that under X-ray irradiation LaF3:Tb3+ SNPs produce hydroxyl radicals ·OH via X-ray induced holes interactions with water molecules adsorbed at the surface of SNPs. Such extra-bonus of LaF3:Tb3+ SNPs can solve the problem of low efficiency of conventional PDT in hypoxic areas of the tumor, which suffer from the lack of oxygen molecules. |
| Databáze: | OpenAIRE |
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