Protecting Against Post-influenza Bacterial Pneumonia by Increasing Phagocyte Recruitment and ROS Production
| Autor: | Zachary Hillberry, Pierre F. Neuenschwander, Vijay Boggaram, Peter F. Barnes, Renuka Subramaniam, Homayoun Shams, Kalyn Fletcher |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Lung Innate immune system Phagocyte business.industry Bacterial pneumonia Drug resistance medicine.disease_cause medicine.disease respiratory tract diseases Microbiology Pneumonia Infectious Diseases medicine.anatomical_structure chemistry Staphylococcus aureus Immunology medicine Immunology and Allergy business |
| Zdroj: | Journal of Infectious Diseases. 209:1827-1836 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jit830 |
| Popis: | Seasonal and especially pandemic influenza predispose patients to secondary bacterial pneumonias, which are a major cause of deaths and morbidity. Staphylococcus aureus is a particularly common and deadly form of post-influenza pneumonia, and increasing staphylococcal drug resistance makes the development of new therapies urgent. We explored an innate immune-mediated model of the lung to define novel mechanisms by which the host can be protected against secondary staphylococcal pneumonia after sub-lethal influenza infection. We found that stimulating the innate immunity in the lung by overexpression of GM-CSF will result in resistance to S. aureus pneumonia after sublethal influenza infection. Resistance was mediated by alveolar macrophages and neutrophils, and was associated with increased production of reactive oxygen species (ROS) by alveolar macrophages. Resistance was abrogated by treatment with agents that scavenged ROS. We conclude that stimulating innate immunity in the lung markedly reduces susceptibility to post-influenza staphylococcal pneumonia and that this may represent a novel immunomodulatory strategy for prevention and treatment of secondary bacterial pneumonia after influenza. |
| Databáze: | OpenAIRE |
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