Cholesterol biosynthesis inhibitory activities of novel triterpenoid acids from Kadsura heteroclita and K. longipedunculata

Autor:	Sadafumi Omura, Hong Xue, Lian-niang Li, Kunio Kangouri, Akiko Ikeda, Toshio Miyoshi
Rok vydání:	1990
Předmět:	Chemistry Cholesterol Stereochemistry Lanosterol Inhibitory postsynaptic potential General Biochemistry Genetics and Molecular Biology Terpenoid chemistry.chemical_compound Biochemistry Biosynthesis Shoot General Agricultural and Biological Sciences Medicinal plants Demethylation
Zdroj:	Agricultural and Biological Chemistry. 54:993-997
ISSN:	1881-1280 0002-1369
Popis:	The effects of twelve novel triterpenoid acids isolated from the ethanolic extract of the stems of Kadsura heteroclita and A. longipedunculata, Chinese folk medicines, and three other novel triterpenoid acids semi-synthesized on cholesterol biosynthesis were examined. (24Z)-3-Oxo-lanosta-8,24-dien-26-oic acid (3-oxo-LA) was most active in depressing cholesterol biosynthesis from [2-14C] mevalonate in a 10,000 × g supernatant fraction of rat liver homogenate. It was suggested from the TLC analysis of radio-labeled products that these compounds inhibit the demethylation of lanosterol. Some triterpenoid acids including 3-oxo-LA also inhibited cholesterol biosynthesis from [1-14C]acetate in primary cultures of rat liver cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cc8fe5c18f9856d4ea6a12197c94de6 https://doi.org/10.1271/bbb1961.54.993 Zobrazit plný text záznamu