Reversibility of Tamoxifen® Retinopathy—A Ten-Year Follow-Up

Autor:	Eberhart Zrenner, Bettina Sadowski, Dorothea Besch
Rok vydání:	2008
Předmět:	medicine.medical_specialty Visual acuity genetic structures business.industry Retinal Macular degeneration medicine.disease Antiestrogen eye diseases Surgery Ophthalmology chemistry.chemical_compound Breast cancer chemistry Decreased Visual Acuity medicine Neurology (clinical) medicine.symptom business Tamoxifen Retinopathy medicine.drug
Zdroj:	Neuro-Ophthalmology. 32:214-221
ISSN:	1744-506X 0165-8107
Popis:	High doses of the non-steroidal oral antiestrogen tamoxifen (60 mg/m/day or more for at least 1 year) may cause decreased visual acuity due to retinal crystalline deposits and other ocular side-effects. A 56-year-old female patient suffering from pulmonary lymphangioleiomyomatosis (BML) with paraneoplastic estradiol production was presented with deterioration of visual acuity because of bilateral macular degeneration after an intake of 190–250 mg/day Tamoxpuren for five years. After discontinuing tamoxifen, ocular side-effects disappeared, perimetric and electrophysiological alterations almost normalized while visual acuity increased internal medical findings remained stable.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cc76ac220a216439ad1b31b37eea20d https://doi.org/10.1080/01658100802114380 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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