Relationship between Exposure to Formaldehyde and Immunoglobulin E (IgE) Production during the Gross Anatomy Laboratory

Autor:	Tomoko Kadota, Chisato Moria, Fumio Nomura, Kimihide Ohmichi, Yoshiharu Matsuno, Hideki Fukata, Yuji Sawabe, Masatoshi Komiyama, Masayoshi Ohmichi, Hidenobu Miyaso
Rok vydání:	2006
Předmět:	Total blood biology business.industry Health Toxicology and Mutagenesis Toxicology Immunoglobulin E Dissection medicine.anatomical_structure Immunology biology.protein Gross anatomy Medicine business Sensitization
Zdroj:	Journal of Health Science. 52:642-647
ISSN:	1347-5207 1344-9702
Popis:	In the gross anatomy laboratory, which is one of the compulsory subjects in most medical and dental schools, participants cannot avoid exposure to formaldehyde (FA), which is emitted from cadavers during dissection. FA has been recognized as a harmful chemical and we have previously reported that symptoms felt by participants in a gross anatomy laboratory are similar to those of allergic diseases. Although immunoglobulin E (IgE)-mediated sensitization to FA is a matter of controversy, it is possible that IgE production is evoked during a gross anatomy laboratory and is responsible for the reported symptoms. In order to test this hypothesis, we examined the relationships between the personal FA exposure levels and plasma IgE levels in a gross anatomy laboratory. In the laboratory, the personal FA exposure levels ranged from 0.33 to 1.47 ppm. Total blood IgE levels did not increase significantly and specific IgE to FA was negative during the laboratory sessions. Thus, from this study, we cannot support the hypothesis that the exposure to FA triggers an IgE-mediated reaction in this study. In conclusion, exposure to FA does not induce IgE production during gross anatomy laboratories at our school.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cbd4a702001188624a7dde09aa34ba9 https://doi.org/10.1248/jhs.52.642 Zobrazit plný text záznamu