Phase ii evaluation of ftorafur in previously untreated colorectal cancer: A southwest oncology group study

Autor:	Carl Groppe, Joseph D. McCracken, Vainutis K. Vaitkevicius, Fernando Padilla, Gerald Guy, Buroker T, Joseph M. Quagliana, Lance K. Heilbrun, B. Hoogstraten
Rok vydání:	1979
Předmět:	Oncology Cancer Research medicine.medical_specialty Group study business.industry Colorectal cancer Metastatic adenocarcinoma medicine.disease medicine.anatomical_structure Internal medicine Toxicity medicine Every Three Weeks Large intestine business Median survival
Zdroj:	Cancer. 44:48-51
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197907)44:1<48::aid-cncr2820440109>3.0.co;2-c
Popis:	Eighty-four previously untreated patients with metastatic adenocarcinoma of the large intestine received intravenous ftorafur at a dosage of 2.25 g/m2/day for 5 consecutive days. Courses were repeated every three weeks. Regressions were noted in 9 of 84 treated patients (11%). Median survival for all patients was 32 weeks. Responders survived only 5 weeks longer than nonresponders; 36 vs. 31 weeks. Central nervous system toxicity was a limiting factor occurring in one-third of patients. Ftorafur in a daily ×5 schedule appears not to make a significant contribution to the management of disseminated colorectal cancer.
Databáze:	OpenAIRE
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