Enhancement Of Immunogenicity of an Immunoprotective Glycophospholipid Antigen of Mycobacteria Using Liposomes Containing Lipid A

Autor:	G. K. Khuller, A. P. Singh
Rok vydání:	1993
Předmět:	Liposome Cholesterol Immunogenicity Pharmaceutical Science Biology Lipid A chemistry.chemical_compound Immune system Biochemistry chemistry Antigen Molar ratio hemic and lymphatic diseases Phosphatidylcholine
Zdroj:	Journal of Liposome Research. 3:303-316
ISSN:	1532-2394 0898-2104
Popis:	Role of liposomes as the carriers of mannophosphoino-sitides (PIMs) antigen of mycobacteria have been investigated. PIMs when incorporated in liposomes made of egg phosphatidylcholine (EPC) and cholesterol (CH)/ in a molar ratio of 2: 1. 5 respectively/ elicited both humoral (anti-PIMs IgG) and cell-mediated (DTH) immune responses in mice. Further/ lipid A containing liposomes as carriers of PIMs were observed to induce almost two times more anti-PIMs immune responses as compared to those without lipid A. These findings clearly establish that the lipid A containing liposomes not only replace FIA, but are even better adjuvants for PIMs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2cabaf76fd9fef8e6a0dd534719f0dc7 https://doi.org/10.3109/08982109309148216 Zobrazit plný text záznamu