Diversity-Oriented Synthesis of Various Enantiopure Heterocycles by Coupling Organocatalysis with Multicomponent Reactions

Autor:	Andrea Basso, Luca Banfi, Samantha Caputo, Renata Riva, Lisa Moni, Andrea Galatini, Chiara Lambruschini
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Enantiopure drug Organocatalysis Nucleophilic substitution Organic chemistry Ugi reaction SN2 reaction Physical and Theoretical Chemistry Mannich reaction
Zdroj:	European Journal of Organic Chemistry. 2017:6619-6628
ISSN:	1434-193X
DOI:	10.1002/ejoc.201701328
Popis:	Chiral, enantiopure 1,3-aminoalcohols, obtained through an organocatalytic Mannich reaction, have been used as inputs in a concise sequence involving diastereoselective Ugi reaction followed by various types of SN2 cyclization. In this way, different enantiopure heterocycles have been prepared, exploring both scaffold and decoration diversity (up to 4 diversity inputs).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2caad4a5b31b93c4aa8125c8bbb7e6c5 https://doi.org/10.1002/ejoc.201701328 Zobrazit plný text záznamu Plný text ve formátu PDF