| Popis: |
Inflammatory bowel disease (IBD) is a chronic condition characterised by leukocyte recruitment to the gut mucosa, where MPO-mediated oxidative damage plays an important role in exacerbating tissue injury. Aim To test whether the MPO-inhibotor, 4-Methoxy TEMPO (MetT), can ameliorate the damaging affects of colitis. Methods Experimental colitis was induced in C57BL/6 mice by administering 3% v/v dextran-sodium-sulphate (DSS) in drinking water ad libitum over 9 days with mice also administered (i.p. injection) MetT (15mg/Kg) or vehicle control (10% DMSO+90% PBS) twice daily during DSS challenge. Results MetT attenuated bodyweight loss (50%, p Conclusion MetT significantly reduced the severity of experimental colitis, though it remains unclear whether MetT actions were mediated via inhibition of MPO or anti-inflammatory pathways, or both. |
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