| Autor: |
Robert E. Graham, Margarito J Uribe, Edward R. Biehl |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Journal of AOAC INTERNATIONAL. 66:264-272 |
| ISSN: |
0004-5756 |
| DOI: |
10.1093/jaoac/66.2.264 |
| Popis: |
A high pressure liquid chromatographic (HPLC) method was developed for the assay of prednisone in bulk drug substances and tablets. The sample was dissolved in water-methanol and an aliquot was analyzed by using HPLC. The average recovery of prednisone added to a prednisone tablet composite was 99.5% with a coefficient of variation of 1.07%. Prednisone was determined in 46 tablets (1-50 mg prednisone/tablet) formulated by 22 manufacturers, using the HPLC method and the USP blue tetrazolium assay. The results show that the HPLC method is more specific and faster than the USP method. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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