Synthesis and characterization of curcumin-loaded pH/reduction dual-responsive folic acid modified carboxymethyl cellulose-based microcapsules for targeted drug delivery
Autor: | Yan Gao, Qingye Meng, Xuejun Cui, Shihao He, Shuangling Zhong |
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Rok vydání: | 2022 |
Předmět: |
chemistry.chemical_classification
Biocompatibility Chemistry General Chemical Engineering technology industry and agriculture PH reduction Ethyl acetate Polysaccharide Combinatorial chemistry Carboxymethyl cellulose chemistry.chemical_compound Targeted drug delivery medicine Curcumin Cellulose medicine.drug |
Zdroj: | Journal of Industrial and Engineering Chemistry. 105:251-258 |
ISSN: | 1226-086X |
Popis: | In the present study, an eco-friendly, biodegradable, biocompatible, non-immunogenic, non-toxic polysaccharide, carboxymethyl cellulose (CMC), derivatived from renewable biomass cellulose, was used for designing and fabrication a folic acid modified pH and reduction dual-responsive carboxymethyl cellulose-based microcapsules (FA-PRCMCs). The curcumin (CUR)-loaded microcapsules (FA-PRCMCs@CUR) were prepared via a quick, efficient and environment-friendly sonochemical method, and were employed for the targeted delivery and pH/reduction dual-stimuli-responsive release of CUR. The excess CUR and ethyl acetate phases could be recycled and reused after preparation of FA-PRCMCs@CUR to avoid wasting resources and polluting the environment. The obtained FA-PRCMCs showed good biocompatibility and targeting in anti-tumor evaluation and endocytosis evaluation in vitro. FA-PRCMCs could effectively reduce the unnecessary damage to normal cells by chemotherapy drugs, and improve the utilization of chemotherapy drugs to reduce therapy costs. FA-PRCMCs could be used as smart targeted delivery vectors and have great clinical application potential. |
Databáze: | OpenAIRE |
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