ChemInform Abstract: Synthesis and Anti-HIV Activity of Arylpiperazinyl Fluoroquinolones: A New Class of Anti-HIV Agents
Autor: | Tetsushi Katsube, Hiroto Kashiwase, Kaoru Shimada, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Takashi Nishigaki, Kenji Momota, Toshinori Ohmine, Satoshi Kimura |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 31 |
ISSN: | 1522-2667 0931-7597 |
Popis: | Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds exhibited potent anti-HIV activity: IC50=0.06 microM in chronically infected cells. |
Databáze: | OpenAIRE |
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