ChemInform Abstract: Synthesis and Anti-HIV Activity of Arylpiperazinyl Fluoroquinolones: A New Class of Anti-HIV Agents

Autor:	Tetsushi Katsube, Hiroto Kashiwase, Kaoru Shimada, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Takashi Nishigaki, Kenji Momota, Toshinori Ohmine, Satoshi Kimura
Rok vydání:	2010
Předmět:	Anti hiv activity chemistry.chemical_compound Piperazine chemistry Anti hiv Aryl virus diseases General Medicine Pharmacology IC50
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
Popis:	Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds exhibited potent anti-HIV activity: IC50=0.06 microM in chronically infected cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2c8de3150135c70f57ad6f1e7c8b785b https://doi.org/10.1002/chin.200007238 Zobrazit plný text záznamu Plný text