Overlapping demyelinating syndromes and anti-N-methyl-D-aspartate receptor encephalitis
| Autor: | Josep Dalmau, Lindsey McCracken, Pamela S. Morales, Tania Cellucci, Markus Reindl, Francesc Graus, Maarten J. Titulaer, Frank Leypoldt, Gagandeep Singh, Makito Hirano, Takahiro Iizuka, Huidy Shu, Albert Saiz, Romana Höftberger, Takashi Irioka, Myrna R. Rosenfeld, Leslie Benson, Kenichi Kaida, Alvaro Cobo Calvo, Tomotaka Yamamoto, Paul W. Wirtz |
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| Rok vydání: | 2014 |
| Předmět: |
Psychosis
Pathology medicine.medical_specialty Neuromyelitis optica medicine.diagnostic_test biology business.industry musculoskeletal neural and ocular physiology Multiple sclerosis Autoantibody Magnetic resonance imaging medicine.disease Myelin oligodendrocyte glycoprotein nervous system Neurology mental disorders medicine biology.protein Neurology (clinical) business Demyelinating Disorder psychological phenomena and processes Encephalitis |
| Zdroj: | Annals of Neurology. 75:411-428 |
| ISSN: | 0364-5134 |
| DOI: | 10.1002/ana.24117 |
| Popis: | Objective To report the clinical, radiological, and immunological association of demyelinating disorders with anti–N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods Clinical and radiological analysis was done of a cohort of 691 patients with anti-NMDAR encephalitis. Determination of antibodies to NMDAR, aquaporin-4 (AQP4), and myelin oligodendrocyte glycoprotein (MOG) was performed using brain immunohistochemistry and cell-based assays. Results Twenty-three of 691 patients with anti-NMDAR encephalitis had prominent magnetic resonance imaging (MRI) and/or clinical features of demyelination. Group 1 included 12 patients in whom anti-NMDAR encephalitis was preceded or followed by independent episodes of neuromyelitis optica (NMO) spectrum disorder (5 cases, 4 anti-AQP4 positive) or brainstem or multifocal demyelinating syndromes (7 cases, all anti-MOG positive). Group 2 included 11 patients in whom anti-NMDAR encephalitis occurred simultaneously with MRI and symptoms compatible with demyelination (5 AQ4 positive, 2 MOG positive). Group 3 (136 controls) included 50 randomly selected patients with typical anti-NMDAR encephalitis, 56 with NMO, and 30 with multiple sclerosis; NMDAR antibodies were detected only in the 50 anti-NMDAR patients, MOG antibodies in 3 of 50 anti-NMDAR and 1 of 56 NMO patients, and AQP4 antibodies in 48 of 56 NMO and 1 of 50 anti-NMDAR patients (p |
| Databáze: | OpenAIRE |
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