Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis
| Autor: | Tae Jun Park, Haneul Oh, Jaehyung Kim, Min Gyu Kim, Sang Wook Son, Hee Joo Kim |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis Toxicology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immune system Psoriasis Medicine General Pharmacology Toxicology and Pharmaceutics Transcription factor integumentary system Epidermis (botany) business.industry Cell growth Public Health Environmental and Occupational Health Particulates medicine.disease In vitro body regions 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology business hormones hormone substitutes and hormone antagonists Stratum basale |
| Zdroj: | Molecular & Cellular Toxicology. 17:195-200 |
| ISSN: | 2092-8467 1738-642X |
| DOI: | 10.1007/s13273-021-00125-w |
| Popis: | Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter. |
| Databáze: | OpenAIRE |
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