40 THE NATURAL HISTORY OF CRYPTOGENIC CIRRHOSIS FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION: A HISTORICAL COHORT STUDY
| Autor: | D. R. Nelson, M. F. Abdelmalek, Chen Liu, N. R. Asal, A. I. Reed, K. Mudaliar, P. W. Stacpoole |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Cirrhosis business.industry Incidence (epidemiology) medicine.medical_treatment Sequela General Medicine Liver transplantation medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology Surgery Internal medicine Hyperlipidemia Cohort Nonalcoholic fatty liver disease medicine Steatosis business |
| Zdroj: | Journal of Investigative Medicine. 53:S393.6-S394 |
| ISSN: | 1708-8267 1081-5589 |
| DOI: | 10.2310/6650.2005.00205.39 |
| Popis: | Background The natural history of cryptogenic cirrhosis (CC) following liver transplantation (LT) is not well defined. Emergence of nonalcoholic fatty liver disease (NAFLD) with steatosis, inflammation (NASH), and cirrhosis has been previously reported. Existing reports are limited by small sample size, lack of follow-up, and the absence of clinicopathologic correlation with the insulin resistance (IR) syndrome. Aim To assess the prevalence, incidence, and risk factors associated with NAFLD in patients (pts) transplanted for CC. Methods All pts with CC transplanted from 1991-2003 were evaluated. Clinical data and all protocol/indication liver biopsies were reviewed and graded for steatosis (0-3), inflammatory (NASH) activity (0-3), and fibrosis (0-4) by a single pathologist blinded to clinical data. Results Clinical Data: LT for CC was performed for 90 of 832 (11%) adult LT pts, mean age 53 ± 12 yrs (range 21-69 yrs), 54% men, and follow-up of 81 ± 62 mo (range 0-170 mo). At LT, the prevalence of hepatoma was 4% and mean calculated MELD score was 16.4 ± 6.2 (range 6-33). Survival: One and five-yr pt survival were 88% and 85% respectively. Repeat LT was required for 4 of 90 (4%). Cardiovascular disease (CVD) deaths occurred in 11 of 27 (41%) pts, 5 (55%) of which were within one yr of LT. Metabolic Parameters: IR was noted in 52% of pts pre-LT. During follow-up, no change was noted in weight, BMI, or glycemic control when compared to pre-LT values (p = ns). During the follow-up period, triglycerides, total and LDL cholesterol increased (p Conclusions NAFLD is a common sequela for pts undergoing LT for CC. Progression to advanced fibrosis was uncommon in this cohort and survival is excellent. IR is present in a majority of patients with CC with CVD is the leading cause of mortality post LT. Hyperlipidemia primarily correlates with recurrent NAFLD post-LT. |
| Databáze: | OpenAIRE |
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