| Autor: |
Herman H Odens Jr., Jae Y You, Alexandria D Gallimore, Preston H Palm, Cameron W Davis, Josue M Bahena, Jeffrey S Moser, Mackenzie E Smith, Herman H Odens |
| Rok vydání: |
2022 |
| DOI: |
10.3762/bxiv.2022.36.v1 |
| Popis: |
A series of novel 2-thio-substituted-3H-phenothiazin-3-ones (6h-l) was effectively synthesized in one pot after optimization of the four-step synthesis. Treatment of a 2-alkylthio-1,4-benzoquinone (3a-l) made in situ and condensed with 1,2-aminothiophenol (5) followed by oxidation with NaIO4 produced the desired final targets. A four-step reaction sequence in which 1,4-benzoquinone (1) is first reacted with an alkylthiol (2a-l) in the presence of sodium periodate (NaIO4) and then treated with 2-aminothiophenol (5) followed by a second oxidation with sodium periodate was demonstrated to be effective in synthesizing 2-thio-substituted-3H-phenothiazin-3-ones (6a-g). The one-pot synthesis is an improvement of the stepwise synthesis of these 2-thio-substituted-3H-phenothiazin-3-one heterocycles since four steps are run in sequence and treated as one. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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