UNRAVELED FRINGE-LIKE MARGINS AND BIPHASIC AUTOFLUORESCENCE OF UNILATERAL RETINAL PIGMENT EPITHELIUM DYSGENESIS
| Autor: | Carol L. Shields, David Ancona-Lezama, Eleni Florakis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures 01 natural sciences Foveola Lesion 03 medical and health sciences Dysgenesis 0302 clinical medicine Ophthalmology medicine 0101 mathematics Retina Retinal pigment epithelium medicine.diagnostic_test business.industry 010102 general mathematics General Medicine Fluorescein angiography eye diseases medicine.anatomical_structure 030221 ophthalmology & optometry sense organs Choroid medicine.symptom business |
| Zdroj: | RETINAL Cases & Brief Reports. 15:709-712 |
| ISSN: | 1935-1089 |
| DOI: | 10.1097/icb.0000000000000880 |
| Popis: | PURPOSE To illustrate the features of unilateral retinal pigment epithelium dysgenesis (URPED) in an African-American male patient. METHODS Case report. RESULTS A 47-year-old asymptomatic African-American man was referred for an atypical subretinal pigmented mass in the left eye. On examination, visual acuity was 20/20 in both eyes. The right eye was unremarkable. The left eye revealed a darkly pigmented grey-black lesion at the level of the RPE with irregular, unraveled fringe-like margins, consistent with URPED. The lesion measured 5 mm in basal dimension and was located 400 μm from the foveola. The dark portion of the lesion was grey-black and demonstrated homogeneous hypoautofluorescence, particularly at the site of grey-white peripheral fringe of fibrous metaplasia. By contrast, there was an additional, subtle lacey arrangement of normal-appearing RPE traversing over the entire lesion demonstrating isoautofluorescence. On fluorescein angiography, the lesion was generally hypofluorescent, particularly in the dark portion of the lesion, but the peripheral fringe of fibrous metaplasia displayed angiographic hyperfluorescent staining, and the subtle lacey normal RPE showed isofluorescence. Optical coherence tomography demonstrated RPE hyperplasia and shallow RPE detachment interspersed with normal-appearing RPE and thinning of outer retina and preservation of the foveola and choroid. CONCLUSION In this case, URPED demonstrated biphasic autofluorescence implying RPE dysfunction in the hypoautofluorescent area and partial RPE function in the lacey isoautofluorescent region. |
| Databáze: | OpenAIRE |
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