| Autor: |
Abha Chopra, Simon Mallal, Christian M. Warren, Morgan C. Lima, Celestine N. Wanjalla, Rama Gangula, Shay Leary, Alyssa M. Hasty, John R. Koethe, Spyros A. Kalams, Briana D. Furch, Curtis L. Gabriel, Joshua D. Simmons, Beverly O. Woodward, Mona Mashayekhi, Ramesh Ram, Wyatt J. McDonnell, Samuel Bailin, LaToya Hannah, Mark A. Pilkinton |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| Popis: |
Persons with HIV (PWH) are at high risk for diabetes mellitus. Adipose tissue T cells are a central regulator of inflammation and adipocyte function, and the known establishment of a HIV reservoir in adipose could contribute to metabolic dysregulation. Here, we show that CD4+ T cell subsets increased in the adipose of diabetic PWH, specifically CD69+ and CD69lo CD57+ GPR56+ CX3CR1+, are clonally expanded with shared T cell receptors, suggesting a common lineage. We observed that both CD69+ and CX3CR1+ CD4+ T cells have transcriptomes consistent with a TH1 profile in diabetics versus TH2 in non-diabetics. CX3CR1+ CD4+ T cells from diabetic PWH also have increased expression of genes in innate immune pathways, not present in CD69+ cells, suggesting functional differences. This study sets the stage for future investigations to determine whether viral antigens in adipose tissue may promote clonal expansion of pro-inflammatory CX3CR1+ and CD69+ CD4+ T cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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