Effect of normal rat serum injected into the uterus on fetal survival in the rat
| Autor: | Eran Hadas, Ian Bukovsky, Reuvit Halperin, Nili Shinnar, David Schneider |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Fetus Fetal viability General Veterinary biology business.industry Fetal Resorption medicine.medical_treatment Uterus Lumen (anatomy) Uterine horns Endocrinology medicine.anatomical_structure Internal medicine medicine biology.protein Animal Science and Zoology Antibody business Saline |
| Zdroj: | Journal of Experimental Animal Science. 42:171-176 |
| ISSN: | 0939-8600 |
| Popis: | Summary We intended to use the rat model to study the effect of autoantibodies on implantation and fetal viability. However, we have since found an effect of normal rat serum on fetal resorption rate and fetal viability. The objective of this study was to determine the consistency of this effect. Wistar strain albino rats were used for injection of 150 μl normal rat serum into the lumen of uterine horn on days L 2 –L 6 . The other uterine horn, used as a control, was injected with 150 μl normal saline. Percent implantation, fetal resorption rate and fetal viability were determined following the intrauterine injection of normal rat serum as compared with normal saline. A significant increase in fetal resorption rate was observed following the injection of rat serum on days L 4 and L 5 (P = 0.003 and P = 0.001, respectively). A significant decrease in fetal viability was demonstrated following the injection of rat serum on day L 5 (P = 0.01). The rat can provide a suitable animal model for further studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect