Prediction of lung cancer patients’ response to combined chemo-radiotherapy using a personalized hybrid model

Autor:	Jarosław Śmieja, Andrzej Świerniak, Rafał Suwiński, Krzysztof Fujarewicz, Monika Kurpas, Sebastian Wołkowicz, Krzysztof Łakomiec
Rok vydání:	2019
Předmět:	Oncology Chemo-radiotherapy medicine.medical_specialty business.industry General Mathematics Tumor response medicine.disease Internal medicine Combined therapy Medicine Decision Sciences (miscellaneous) business Lung cancer Hybrid model Survival analysis
Zdroj:	Mathematica Applicanda. 47
ISSN:	2299-4009 1730-2668
Popis:	The paper presents a novel approach to the prediction of the combined therapy outcome for non-small lung cancer patients. A hybrid model is proposed, consisting of two parts. The first one is a mathematical model of tumor response to therapy, whose parameters are expressed as linear function of data from massspectrometry of patient blood plasma samples. These linear functions constitute thesecond component of the hybrid model. A comparison of clinical and simulation-based survival curves is used to evaluate the quality of the model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2c5814e9d40de9ba5869cd5446bd93aa https://doi.org/10.14708/ma.v47i2.6486 Zobrazit plný text záznamu