Hardware Design and Experimental Demonstrations for Digital Acoustofluidic Biochips
| Autor: | James C. Morizio, Haodong Zhu, Zhanwei Zhong, Krishnendu Chakrabarty, Peiran Zhang, Tony Jun Huang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
business.industry Computer science Amplifier Microfluidics 02 engineering and technology Signal 020202 computer hardware & architecture Form factor (design) 03 medical and health sciences 030104 developmental biology Coupling (computer programming) Transmission (telecommunications) Hardware_INTEGRATEDCIRCUITS 0202 electrical engineering electronic engineering information engineering Hardware_ARITHMETICANDLOGICSTRUCTURES Routing (electronic design automation) business Biochip Computer hardware |
| Zdroj: | BioCAS |
| DOI: | 10.1109/biocas.2019.8919148 |
| Popis: | A digital microfluidic biochip (DMB) is an attractive platform for automating laboratory procedures in microbiology. To overcome the problem of cross-contamination due to fouling of the electrode surface in traditional DMBs, a contactless liquid-handling biochip technology, referred to as acoustofluidics, has recently been proposed. A major challenge in operating this platform is the need for a control signal of frequency 24 MHz and voltage range ±10/ ±20 V to activate the inter-digital-transducer (IDT) units in the biochip. A preliminary solution based on amplifiers, mechanical relays, and jump wires introduces signal loss (at least 6dB), signal coupling, and waveform distortion. In this paper, we present a new IDT-driver design that offers three major advantages: smaller form factor and lower cost, effective and high-quality signal generation and transmission, and fully-automated and flexible biochip control. Experimental demonstrations of droplet routing and a simple bioassay highlight the effectiveness of our hardware design. |
| Databáze: | OpenAIRE |
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