Genetic testing experience of a private fertility clinic
| Autor: | Pierre St-Michel, Serge B. Melançon, Myriam Pelletier, S. Demczuk, François Bénard |
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| Rok vydání: | 2004 |
| Předmět: |
Infertility
Azoospermia Gynecology Pediatrics medicine.medical_specialty medicine.diagnostic_test Y chromosome microdeletion Incidence (epidemiology) General Medicine Severe oligospermia Biology urologic and male genital diseases medicine.disease Fertility clinic Male infertility medicine Genetic testing |
| Zdroj: | International Congress Series. 1271:177-180 |
| ISSN: | 0531-5131 |
| DOI: | 10.1016/j.ics.2004.05.037 |
| Popis: | The objective of the study was to assess the frequency of Y-chromosome microdeletions and cytogenetic rearrangements in couples presenting with a male factor-infertility and to evaluate under which indications these genetic analysis should be recommended. Y-chromosome microdeletions were detected in 4.6% of patients with altered spermatogenesis. The incidence of deletion Yq was 13.3% in males with non-obstructive severe oligospermia and azoospermia. The incidences of chromosome anomalies and of chromosome variants were 2.1% and 0.6% respectively. Our study confirms that a subgroup of men with azoospermia and severe oligospermia are at high risk for Y-chromosome microdeletions. It is therefore recommended to screen them for microdeletions of the Y-chromosome before applying ICSI treatment for infertility. Cytogenetic evaluation is also justifiable as part of the investigation for these patients. |
| Databáze: | OpenAIRE |
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