629 IMPACT OF SMOKING STATUS AT DIAGNOSIS ON DISEASE RECURRENCE AND DEATH IN CLEAR CELL RENAL CELL CARCINOMA
| Autor: | Helena Furberg, A. Ari Hakimi, Emily C. Zabor, Behfar Ehdaie, Paul Russo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Predictive marker business.industry Urology medicine.medical_treatment Disease urologic and male genital diseases medicine.disease Logistic regression Nephrectomy Pre operative Log-rank test Clear cell renal cell carcinoma Internal medicine medicine Smoking status business |
| Zdroj: | Journal of Urology. 189 |
| ISSN: | 1527-3792 0022-5347 |
| Popis: | age 55.4 12.5(SD)) was 246.3 62.5cc. Pre operative eGFR was 84.3 18.9 ml/min/1.73 m2. Over a median follow-up of 36 months, progression to CKD occurred in 42.6% (n 32) patients. Univariable logistic regression analysis showed that renal volume (p 0.01, HR 2.61 95%CI 1.25-5.43), age (p 0.002, HR 1.05 95%CI 1.02-1.09), male gender (p 0.02, HR 2.86 95%CI 1.18-7.14) and pre-operative GFR (p 0.002, HR 0.96 95%CI 0.93-0.98) were associated with postoperative CKD. The ROC area with pre-operative renal volume as a predictor of post-operative CKD was 0.65 (95% CI 0.53 to 0.78). Kaplan Meier analysis showed the median time to CKD after nephrectomy was 22.3 (0-87.6) months for renal volume less than 236cc (log rank p 0.008) but this was not achieved if renal volume is more than 236cc (Figure 1). CONCLUSIONS: Total renal volume measured using ImageJ before radical nephrectomy is associated with development of postoperative CKD. In addition, a total pre-operative renal volume of less than 236 cc can be used as surrogate predictive marker of CKD development after radical nephrectomy. |
| Databáze: | OpenAIRE |
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